PEA

[Griff522]

I'm a newbie when it comes to research but I stumbled across this and thought I would share

http://onlinelibrary.wiley.com/doi/10.1 ... x/abstract

[Karyn]

Sounds interesting! Is anyone able to view the full article? I'm still not sure what it is or how it works.
Thanks, Griff!
Warm regards,
Karyn

[Violet M]

I can see how this might be helpful in case of an inflammation but I think there are certain types of entrapments that could not be helped just by taking an anti-inflammatory drug. Here is a copy of the abstract in case the link eventually quits working.

Abstract

Background.  Pudendal neuralgia is a cause of chronic, disabling, and often intractable perineal pain presenting as burning, tearing, sharp shooting, foreign body sensation, and it is often associated with multiple, perplexing functional symptoms.

Case Report.  We report a case of a 40-year-old man presenting with chronic pelvic pain due to pudendal nerve entrapment and successfully treated with palmitoylethanolamide (PEA).

Conclusion.  PEA may induce relief of neuropathic pain through an action upon receptors located on the nociceptive pathway as well as a more direct action on mast cells via an ALIA (autocoid local injury antagonism) mechanism.

As recently demonstrated in animal models, the present case suggests that PEA could be a valuable pharmacological alternative to the most common drugs (anti-epileptics and antidepressants) used in the treatment of neuropathic pain.

[Cora]

Interesting, as this is getting some attention on another pelvic pain site. My understanding is that it is only available in Europe. If people are interested, I could try to get more info.
And to confuse you a little more, I have a new user name...once again.. But have the same old avatar, same old me, same old signature.
Anyway... as for PEA, it's garnering some attention here, just not sure about local availability.

Cora

[PN-SufferVT]

My wife is a doc, I will have her get the full article from the hospital computer. I'll keep everyone posted.

[PN-SufferVT]

I found some great research on this. However, it is in Italian, so you will need to open it in Google Chrome Browser to translate. It is called Normast overseas and it looks like they are have a lot of success treating pelvic pain with it.....

In pudendal neuropathic pain palmitoylethanolamid reduced the pain scores in a clinical relevant way. [8] In another paper the positive effects on pelvic pain were reported. [9] Animal studies are also supportive for the use of this supplement in the treatment of neuropathic pain. [10]

[8]: Calabrò RS, Gervasi G, Marino S, Mondo PN, Bramanti P. | Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. | Pain Med. | 2010 May;11(5):781-4. Epub 2010 Mar 22.
[9]: Indraccolo U, Barbieri F. | Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. | Eur J Obstet Gynecol Reprod Biol. | 2010 May;150(1):76-9. Epub 2010 Feb 21.

http://www.epitechgroup.it/scripts/sys/ ... gina_id=28

[PN-SufferVT]

Interesting, as this is getting some attention on another pelvic pain site. My understanding is that it is only available in Europe. If people are interested, I could try to get more info.
And to confuse you a little more, I have a new user name...once again.. But have the same old avatar, same old me, same old signature.
Anyway... as for PEA, it's garnering some attention here, just not sure about local availability.

Cora

What other site is it getting attention on?

[Cora]

sorry for the delayed response, the site that a lot of people are using this on is the yahoo site, Happy Pelvis

Cora

[PN-SufferVT]

Hey Everyone,
Here is a new study on PEA for CTS of the wrist..... I have also found a website where you may purchase PEA..... it is really promising!

Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist.
Conigliaro R, Drago V, Foster PS, Schievano C, Di Marzo V.
Source
Operative Unity of Neurology, Siracusa, Italy - robconi@tin.it.
Abstract
AIM:
Carpal tunnel syndrome (CTS) is a medical condition in which the median nerve is compressed, leading to discomfort and pain. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, able to modulate inflammatory cell reactivity and pain. This study deals with the capability of PEA to normalize the electroneurographic alterations associated with moderate CTS.

METHODS:
Patients displaying moderate CTS were enrolled and daily PEA (600 mg or 1 200 mg/die) was administered for 30 days. Control group received no treatment.

RESULTS:
PEA treatment significantly improved the CTS-induced reduction of median nerve latency time (P<0.0004); PEA effect was dose-dependent. Tinel's sign presence and symptoms of discomfort were also reduced.

CONCLUSION:
Although further studies are needed to better characterize PEA effect, the present report represents the first evidence on the improvement of distal motor latency elicited by PEA in patients with moderate CTS. The data support the hypothesis of protection against inflammatory and neuropathic pain by PEA.

[Bladder Facts]

Hello,

Yesterday I started a new topic, see http://www.pudendalhope.info/forum/view ... =25&t=2243

Maybe we could start again talking about the compound Palmitoylethanolamide.

I have lots of new articles....