christi wrote: Where can I find more information on the connection of autoimmunity and PN? I haven't heard anyone on the boards discussing this, but I assume that whoever wrote this must have had good reasons for including it as a possible cause.i
An autoimmune illness such as multiple sclerosis in which the myelin sheath is damaged or diabetes causing nerve damage could cause pudendal neuropathy. As far as finding scholarly articles on the subject that's tricky because most of us only have access to article abstracts rather than the full text of articles. But as Spikehead said, if it's due to an autoimmune disease you most likely will have other accompanying symptoms.
Here' are a couple of articles:
Neurophysiol Clin. 1997;27(1):51-8.
[Penile neuropathy: clinical and electrophysiologic study. Report of 186 cases].
[Article in French]
Amarenco G, Bosc S, Goldet R.
Source
Laboratoire d'urodynamique et de neurophysiologie, Centre hospitalier Robert Ballanger, Aulnay-sous-Bois, France.
Abstract
Penile neuropathy is a common disease due to lesion of the sensory branch of the pudendal nerve, ie, the dorsal nerve of the penis. Sexual disorders (deterioration of erection) and sensory signs (hypoesthesia or paresthesia of the penis) are noted in patients with penile neuropathy. Electrophysiological recordings help guide the diagnosis (reduction of the sensory velocity of the dorsal nerve of the penis). Many etiologies can be found (traumatic, toxic, compressive), but the most common lesion is neuropathy related to diabetes.
PMID: 9206758 [PubMed - indexed for MEDLIN
Int J Colorectal Dis. 1994 May;9(2):105-9.
Pudendal neuropathy in diabetic patients with faecal incontinence.
Pinna Pintor M, Zara GP, Falletto E, Monge L, Demattei M, Carta Q, Masenti E.
Source
University of Turin, Italy.
Abstract
To investigate the pathophysiology of faecal incontinence in diabetes mellitus, two groups of diabetic patients were studied: 14 subjects (7 females and 7 males, mean age 57 +/- 9 years) with faecal incontinence (Group A) and 15 subjects (6 females and 9 males, mean age 54.7 +/- 8 years) without faecal incontinence but affected by somatic peripheral neuropathy. A third group (C) of 10 healthy volunteers was used as controls. All subjects underwent electroneurographic evaluation of peripheral neuropathy, pudendal nerve terminal motor latency, anorectal manometry and rectal sensitivity tests. All the patients of group A had somatic peripheral neuropathy. Maximum squeeze pressure was lower in A compared to C (P < 0.025) and sustained for a shorter period in A compared with B (P < 0.0005) and C (P < 0.0005). All rectal sensitivity thresholds were higher in A compared with B and C. Pudendal Nerve Terminal Motor Latency was prolonged in 93% of patients studied in group A and in 73% of patients in group B (A vs B P < 0.005), with a significant difference in comparison with C: A vs C P < 0.0005, B vs C P < 0.005. Our findings suggest that somatic neuropathy plays an important role in faecal incontinence in diabetic patients, combined with sensation threshold impairment as a feature of an autonomic involvement.
PMID: 8064189 [PubMed - indexed for MEDLINE]