ETNA - New Brazil lab medication

[bma]

Hello,

In Brazil some drugs have focused on the treatment of neuralgia, in particular the intramuscular injection DEXACitoneurin (B1 + B6 + B12 + Dexamethasone) and new drug very interesting to be specifically focused in diseases of nerve compression, which is the ETNA . Still not used, but will use. For the skeptics, its NOT a natural medicine, he sets out to restore the myelin sheath. For people who speak Portuguese or Spanish, you can read the label.

The substance acts on the metabolic chain and DNA, regenerating the damaged region.

http://www.gross.com.br/pdf/ETNA_BU11003%2001.pdf

ETNA ®
disodium phosphate of cytidine
uridine triphosphate trisodium
hydroxocobalamin acetate
lidocaine hydrochloride ( injectable pharmaceutical form )
DOSAGE FORMS AND PRESENTATIONS - ETNA

Capsule . Box of 20 capsules . Powder injection liófilo + diluent solution . Box of 3 vials of lyophilisate and 3 vials of diluent .

ADULT and PEDIATRIC USE

COMPOSITION - ETNA

Each capsule contains :
disodium cytidine ( CMP ) .................... 2.5 mg
trisodium uridine triphosphate ( UTP ) .................... 1.5 mg
hydroxocobalamin acetate .................... 1.0 mg
Excipient qsp .................... ................... 1 capsule
Excipients: citric acid , sodium citrate , silicon dioxide , magnesium stearate , mannitol .
Each vial of lyophilized contains :
disodium cytidine ( CMP ) .................... 5.0 mg
trisodium uridine triphosphate ( UTP ) .................... 3.0 mg
hydroxocobalamin acetate .................... 2.0 mg
Excipients : mannitol .
Each vial of diluent contains :
lidocaine hydrochloride .................... 20.0 mg
Excipente .................... ................... qs 2.0 ml
Excipients : sodium chloride , water for injection .
PATIENT INFORMATION - ETNA

Expected action of a drug medicamentoEtna ® is indicated for the treatment of some types of peripheral nerve disorder such as trauma or local compression .
Indications of the drug
Diseases of the peripheral nerves .
Risks of the medication
History of allergy to its components (see the section Composition ) . Tell your doctor if you : ( 1 ) is diagnostic investigation or is a carrier ( a) of proliferative disease , (2 ) it makes use of antiviral drugs or drug citicoline , (3 ) for injectable pharmaceutical form : it carries cardiac or neurological disease (convulsions , epilepsy ), or using the following drugs : cimetidine , propranolol , nadolol , amprenavir , ritonavir or anti-arrhythmic drugs .
CATEGORY OF DRUGS USED TO PREGNANT WOMEN ( capsule dosage form ) : C ( no studies in animals and even in pregnant women , this medication should not be used by pregnant women without medical or dental surgeon ) .
CATEGORY OF DRUGS USED TO PREGNANT WOMEN ( injectable pharmaceutical form ) : D [ drug ( lidocaine ) demonstrated positive evidence of human fetal risk , however , the potential benefits for women can possibly justify the risk , for example , in cases of serious illness or that threaten life , and for which no other safer drugs , this medicine should not be used by pregnant women without medical guidance ] .
" Tell your doctor or dentist the appearance of undesirable reactions. "
" Tell your doctor or dentist that you are making use of any other drug. "
"Do not take medication without your doctor's knowledge . Could be hazardous to your health "
" There is no contraindication for the ages. "
How to use
Etna ® capsules are to be taken orally and Etna ® injection , by intramuscular injection . Etna ® capsules capsules have a pink and Etna ® injectable comes in a vial with powder and one jar with thinner . The dosage should respect the prescription. Consult your doctor if you forget to take a dose.
" Do not stop treatment without the knowledge of your doctor . "
" Follow the guidance of your doctor respecting schedules, doses and duration of treatment . "
" Do not use medicine with expiry date . Prior to use, note the appearance of the product. "
" This medicine should not be chewed or crushed . "
adverse Reactions
Tell your doctor the appearance of any unpleasant reaction .
Conduct in case of overdose
Seek emergency medical service for guidance.
Care use and conservation
Capsules: keep the product under moisture. Avoid excessive heat (temperature above 40 ° C ) . Injectable : Keep the medication away from light . Avoid excessive heat (temperature above 40 ° C ) .
"Every medicine should be kept out of reach of children . "
" Etna ® capsules should be consumed immediately after removal of the capsule from its blister . "
" Etna ® Injection should be administered immediately after dilution of the contents of the vial of lyophilized . "
TECHNICAL INFORMATION - ETNA

- CLINICAL PHARMACOLOGY
Etna ® is composed of ribonucleotides and pyrimidine CMP UTP RNA extracted from pancreatic degraded by a ribonuclease and connected radicals sodium , making it therefore a salt. Its pharmacological role consists in integrating the synthetic pathways of myelin and neuronal cell membrane as a transfer molecule , such as RNA precursors such as neuronal and neuronal P2Y receptor agonists , especially in situations of enhanced biochemical synthesis , such as during regenerative processes . Mechanical disintegration of the binomial axon - glial be followed by a regenerative - degenerative process in which the speed of myelin and axolemais anabolic pathways as well as the rate of transcription and translation genomic be accelerated. As an integral part of these processes, together with other important metabolites , nucleotides should be used in an amount higher than baseline . As a further fact , it is known that neurons are not self- sufficient regarding recycling and synthesis of nucleotides from fundamental metabolic precursors , depending largely on the external input nucleoside , even under basal conditions ( experimental data ) . It would therefore necessary to supplement their anabolic accelerated conditions , either in the form physiologically or pharmacologically replacement . The agonist Etna ® nucleotide P2Y on the nervous system leads to an increased synthesis of fostatidilcolina neuronal cell membrane . In diabetes mellitus, UTP will counteract the inhibition of phosphatidylinositol caused by sorbitol. Obviously , the optimal control of neuropathic symptoms will be predominantly dependent on the adequate control of blood glucose . The mechanism of action of Etna ® in alcoholic polyneuropathy is not yet fully elucidated . Vitamin B12 in the form of hydroxocobalamin , it is a cofactor in the conversion of homocysteine ​​to methionine , which is an amino acid which composes the axonal tubulin . This property helps in restoring neuronal transport system . Lidocaine is a local anesthetic of the amide type , which has the function of relieving the pain caused by intramuscular injection of Etna ® injection. Its mechanism of action is based on its blocking the fast sodium channels of nerve endings sites , thus preventing the transmission of nerve impulses . Its pharmacokinetic data corresponding to the IM route of administration are: (1 ) Tmax 30 min to 2 h , (2) t1/2b 1.5 to 2 h , (3) rate of 90% of hepatic metabolism , and (4 ) rate of excretion kidney 90%. Lidocaine metabolites less potent and less toxic than the parent drug , are monoethylglycinexylidide ( monoetilglicina and subsequently metabolized to N- ethylglycine ) and glicinexilidida .
INDICATIONS - ETNA

( 1 ) trauma disorders , peripheral nerve compression : extrinsic compression ( fractures , vertebral syndrome ) , neural Stretch injuries ( sprains ) , injury by laceration ( by sectioning bone fragment damage by sharp object ) , vibration injuries [ use of machines ( RSI / WMSD ) ] , surgical procedures or neural structures contiguous , (2 ) and sciaticas cervicobrachialgias , (3 ) alcoholic polyneuropathy , ( 4 ) diabetic neuropathy .

[BedBug]

See also:

http://www.medicine.nevada.edu/wps/Proc ... 3_5-12.pdf

[jameskramer]

To treat this kind of illness, you must consult a doctor. Normally your doctor usually will prescribe medications to lessen or block the pain signals sent to your brain.

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